ABSTRACT
AIM:To investigate and evaluate the effectiveness and safety of tobramycin and dexamethasone ointment in the treatment of blepharitis.METHODS:We searched in Pubmed,Medline,Embase,Elsevier,Cochrane Library,Wangfang database,CNKI,VIP database,Sinomed database,and gray literature were performing manual.The efficiency,intraocular pressure,adverse reactions and extract valid data were evaluated.RESULTS:Totally 8 controlled trials were enrolled,including 970 patients.Compared with control groups,the efficiency and the intraocular pressure in experiment group had a statistically significant increase (RR=1.75,95％ CI=1.29-2.37,P=0.0003;SMD=1.30,95％ CI=0.85-1.75,P＜0.00001),and there was no statistic difference in adverse reactions (RR =1.64,95％ CI =0.86-3.10,P =0.13).CONCLUSION:Tobramycin and dexamethasone ointment in treatment of blepharitis is effective with no adverse effects.Due to the quality of the literature is low,there is still need high quality randomized controlled trials.